Background: Despite advancement in our knowledge of different treatment options for people living with psychotic disorders, many psychiatrists and public mental health services are often faced with challenging cases that do not always respond to conventional treatment guidelines.

Objectives: To explore different treatment options for people with treatment refractory schizophrenia.

Methods: Five clinical researchers who work in public mental health services will present current evidence bases for different modes of treatment available for people with psychotic disorders.

Findings: There are many potentially effective treatment options for people with treatment refractory schizophrenia.

Conclusions: Improving treatment response for people with psychotic disorders is possible. However, it requires an organizational response to provide a comprehensive care with different treatment dimensions combining biological, psychosocial interventions as well as technology utilization and physical health monitoring.