Rhythmic growth hormone secretion in physiological and pathological conditions: Lessons from rodent studies

No Thumbnail Available
File version
Author(s)
Huang, L
Huang, Z
Chen, C
Griffith University Author(s)
Primary Supervisor
Other Supervisors
Editor(s)
Date
2019
Size
File type(s)
Location
License
Abstract

Evolutionally conserved in all mammalians, the release of GH occurs in a rhythmic pattern, characterized by several dominant surges (pulsatile GH) with tonic low inter-pulse levels (tonic GH). Such pulsatile secretion pattern is essential for many physiological actions of GH on different tissues with defined gender dimorphism. Rhythmic release of pulsatile GH is tightly controlled by hypothalamic neurons as well as peripheral metabolic factors. Changes of GH pattern occur within a range of sophisticated physiological and pathological settings and significantly contribute to growth, ageing, survival and disease predispositions. Precise analysis of GH secretion pattern is vitally important for a comprehensive understanding of the function of GH and the components that regulate GH secretion pattern.

Journal Title
Molecular and Cellular Endocrinology
Conference Title
Book Title
Edition
Volume
498
Issue
Thesis Type
Degree Program
School
Publisher link
Patent number
Funder(s)
Grant identifier(s)
Rights Statement
Rights Statement
Item Access Status
Note
Access the data
Related item(s)
Subject
Biological sciences
Agricultural, veterinary and food sciences
Biomedical and clinical sciences
Endocrinology
Ageing
Diabetes
Fasting
Gender dimorphism
Growth hormone
Persistent link to this record
Citation
Huang, L; Huang, Z; Chen, C, Rhythmic growth hormone secretion in physiological and pathological conditions: Lessons from rodent studies, Molecular and Cellular Endocrinology, 2019, 498, pp. 110575: 1-110575: 8
Collections