The Prognostic Role of Circulating Tumor Cells (CTCs) in Lung Cancer

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Kapeleris, Joanna
Kulasinghe, Arutha
Warkiani, Majid E
Vela, Ian
Kenny, Liz
O' Byrne, Kenneth
Punyadeera, Chamindie
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2018
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https://creativecommons.org/licenses/by/4.0/
Abstract

Lung cancer affects over 1. 8 million people worldwide and is the leading cause of cancer related mortality globally. Currently, diagnosis of lung cancer involves a combination of imaging and invasive biopsies to confirm histopathology. Non-invasive diagnostic techniques under investigation include "liquid biopsies" through a simple blood draw to develop predictive and prognostic biomarkers. A better understanding of circulating tumor cell (CTC) dissemination mechanisms offers promising potential for the development of techniques to assist in the diagnosis of lung cancer. Enumeration and characterization of CTCs has the potential to act as a prognostic biomarker and to identify novel drug targets for a precision medicine approach to lung cancer care. This review will focus on the current status of CTCs and their potential diagnostic and prognostic utility in this setting.

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Frontiers in Oncology
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© 2018 Kapeleris, Kulasinghe, Warkiani, Vela, Kenny, O'Byrne and Punyadeera. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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Oncology and carcinogenesis
Science & Technology
Life Sciences & Biomedicine
Oncology
lung cancer
NSCLC
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Kapeleris, J; Kulasinghe, A; Warkiani, ME; Vela, I; Kenny, L; O' Byrne, K; Punyadeera, C, The Prognostic Role of Circulating Tumor Cells (CTCs) in Lung Cancer, Frontiers in Oncology, 2018, 8, pp. 311
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