Objective This scoping review aims to assess the current research landscape of the application and use of large language models (LLMs) and generative Artificial Intelligence (AI), through tools such as ChatGPT in telehealth. Additionally, the review seeks to identify key areas for future research, with a particular focus on AI ethics considerations for responsible use and ensuring trustworthy AI.

Materials and Methods Following the scoping review methodological framework, a search strategy was conducted across 6 databases. To structure our review, we employed AI ethics guidelines and principles, constructing a concept matrix for investigating the responsible use of AI in telehealth. Using the concept matrix in our review enabled the identification of gaps in the literature and informed future research directions.

Results Twenty studies were included in the review. Among the included studies, 5 were empirical, and 15 were reviews and perspectives focusing on different telehealth applications and healthcare contexts. Benefit and reliability concepts were frequently discussed in these studies. Privacy, security, and accountability were peripheral themes, with transparency, explainability, human agency, and contestability lacking conceptual or empirical exploration.

Conclusion The findings emphasized the potential of LLMs, especially ChatGPT, in telehealth. They provide insights into understanding the use of LLMs, enhancing telehealth services, and taking ethical considerations into account. By proposing three future research directions with a focus on responsible use, this review further contributes to the advancement of this emerging phenomenon of healthcare AI.