Neurological Mechanisms Underlying Exercise-Induced Fatigue in Multiple Sclerosis

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Brotherton_Emily_Final Thesis.pdf
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Sabapathy, Surendran

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Morris, Norman

Kavanagh, Justin J

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2024-05-15
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Abstract

Fatigue is reported as the most debilitating symptom in people with Multiple Sclerosis (MS). Greater levels of exercise-induced fatigue have been documented in people with MS compared to healthy controls across a wide range of fatiguing contraction protocols. Existing literature suggests that exercise-induced fatigue in MS may be related to a decline in neural drive to the muscle, however, the underlying neurophysiological mechanisms remain unclear. Many investigations have examined the motor system in MS during fatiguing contractions however, much disparity exists due to the variability of techniques to assess neural drive as well as duration and intensity of the contraction protocols employed.

This Thesis consists of three experiments which examine the neurophysiological mechanisms that contribute to the objective measure of fatigue (performance fatigability) in people with MS. Electromyography (EMG), motor nerve stimulation (MNS), and transcranial magnetic stimulation (TMS) of the motor cortex were used to assess different levels of the motor system during fatiguing contractions of the upper limb in people with MS compared to healthy controls. [...]

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Thesis (PhD Doctorate)

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Doctor of Philosophy

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School of Health Sci & Soc Wrk

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The author owns the copyright in this thesis, unless stated otherwise.

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Subject

performance fatigability

multiple sclerosis

neurophysiology

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