Comparative Study of Hemagglutination and Lectin Activity in Australian Medicinal Mushrooms (Higher Basidiomycetes)

No Thumbnail Available
File version
Author(s)
Rouf, Razina
Tiralongo, Evelin
Krahl, Anja
Maes, Karen
Spaan, Lina
Wolf, Stefan
May, Tom W
Tiralongo, Joe
Griffith University Author(s)
Primary Supervisor
Other Supervisors
Editor(s)
Solomon P. Wasser
Date
2011
Size
File type(s)
Location
License
Abstract

Fifteen Australian mushroom species (higher Basidiomycetes) were assessed for hemagglutination and lectin activity. Hemagglutination activity was evaluated using both neuraminidase treated and untreated rabbit and human A, B, and O erythrocytes. Lectin activity was determined by the ability of various mono- and oligosaccharides to inhibit hemagglutination activity. Of the mushrooms evaluated, seven contained lectin activity. However, five (Agaricus bitorquis, Chlorophyllum brunneum, Coprinus comatus, Cortinarius sp. TWM 1710, and Omphalotus nidiformis) expressed lectin activity in only one of two collections tested. The two remaining lectin active mushroom species (Phlebopus marginatus and Psathyrella asperospora) possessed lectin activity with the same sugar specificity in both collections. Although lectins were identified with diverse specificity, lactose-specific lectin activity was most frequently identified, being present in Agaricus bitorquis, Copronus comatus, Omphalotus nidiformis, and Phlebopus marginatus. In contrast, Psathyrella asperospora, Cortinarius sp. TWM 1710, and Chlorophyllum brunneum were found to possess lectin activity specific for N-acetyl-D-glucosamine, galactose, and N-acetyl-neurammic acid, respectively. Significantly, the galactose-specific lectin activity identified in Cortinarius sp. TWM 1710 and the lactose-specific lectin activity in Phlebopus marginatus have not been previously reported.

Journal Title
International Journal of Medicinal Mushrooms
Conference Title
Book Title
Edition
Volume
13
Issue
6
Thesis Type
Degree Program
School
Publisher link
Patent number
Funder(s)
Grant identifier(s)
Rights Statement
Rights Statement
Self-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.
Item Access Status
Note
Access the data
Related item(s)
Subject
Biochemistry and cell biology not elsewhere classified
Pharmacology and pharmaceutical sciences
Persistent link to this record
Citation
Collections