Tissue Engineered Constructs for Periodontal Regeneration: Current Status and Future Perspectives

No Thumbnail Available
File version
Author(s)
Vaquette, Cedryck
Pilipchuk, Sophia P
Bartold, P Mark
Hutmacher, Dietmar W
Giannobile, William V
Ivanovski, Saso
Primary Supervisor
Other Supervisors
Editor(s)
Date
2018
Size
File type(s)
Location
License
Abstract

The periodontium, consisting of gingiva, periodontal ligament, cementum, and alveolar bone, is a hierarchically organized tissue whose primary role is to provide physical and mechanical support to the teeth. Severe cases of periodontitis, an inflammatory condition initiated by an oral bacterial biofilm, can lead to significant destruction of soft and hard tissues of the periodontium and result in compromised dental function and aesthetics. Although current treatment approaches can limit the progression of the disease by controlling the inflammatory aspect, complete periodontal regeneration cannot be predictably achieved. Various tissue engineering approaches are investigated for their ability to control the critical temporo‐spatial wound healing events that are essential for achieving periodontal regeneration. This paper reviews recent progress in the field of periodontal tissue engineering with an emphasis on advanced 3D multiphasic tissue engineering constructs (TECs) and provides a critical analysis of their regenerative potential and limitations. The review also elaborates on the future of periodontal tissue engineering, including scaffold customization for individual periodontal defects, TEC's functionalization strategies for imparting enhanced bioactivity, periodontal ligament fiber guidance, and the utilization of chair‐side regenerative solutions that can facilitate clinical translation.

Journal Title

ADVANCED HEALTHCARE MATERIALS

Conference Title
Book Title
Edition
Volume

7

Issue

21

Thesis Type
Degree Program
School
Publisher link
Patent number
Funder(s)
Grant identifier(s)
Rights Statement
Rights Statement
Item Access Status
Note
Access the data
Related item(s)
Subject

Medicinal and biomolecular chemistry

Biomedical engineering

Medical biotechnology

Persistent link to this record
Citation
Collections