A Facile and Efficient Method for the Synthesis of Novel Pyridone Analogues by Aminolysis of an ester Under Solvent-Free Conditions
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Karis, N David
Loughlin, Wendy A
Jenkins, Ian D
Loughlin, Wendy A
Jenkins, Ian D
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2007
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Abstract
A series of 15 pure novel N-alkylated pyridone derivatives have been synthesized in 73-96% yields on treatment of ethyl (2-pyridone)acetates with structurally diverse amines in an efficient aminolysis procedure under 'solvent-free' conditions.
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Tetrahedron
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63
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Medicinal and biomolecular chemistry
Organic chemistry