Mild hyperbilirubinaemia as an endogenous mitigator of overweight and obesity: Implications for improved metabolic health

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Seyed Khoei, N
Grindel, A
Wallner, M
Mölzer, C
Doberer, D
Marculescu, R
Bulmer, A
Wagner, KH
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2018
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Abstract

Background and aims: Mild endogenous elevation of unconjugated bilirubin (UCB) as seen in Gilbert's syndrome (GS), might mitigate cardiovascular disease (CVD) risk factors including overweight/obesity. This study aimed to determine whether hyperbilirubinaemia is linked to improved anthropometric data and lipid profile. Methods: Our study considered GS and age-/gender-matched healthy controls (n ¼ 248). Additionally, obese female type 2 diabetic patients (DM2) (n ¼ 26) were included as a “disease control group”. Results: BMI, hip circumference (HC), and lipid profile were significantly lower in GS. UCB was inversely correlated with BMI (p <0 .001), HC as well as with fat mass (FM) and lipid variables (p < 0.05). Moreover, DM2 patients had significantly lower UCB compared to GS and healthy controls. Older GS subjects (35 years) had significantly reduced anthropometric data and improved lipid profile. Conclusions: Our results propose that the health promoting potential of mild hyperbilirubinaemia may extend to protection from age-related weight gain and dyslipidaemia.

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Atherosclerosis

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269

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© 2018 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.

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Cardiovascular medicine and haematology

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Clinical sciences not elsewhere classified

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