The quality of working life became an important topic in the 1960s and 1970s, helping to stimulate an early approach to evidence-based policy advocacy drawing on interdisciplinary research by social scientists. Over the years it fell out of the limelight but much relevant, albeit fragmented, research has continued. We present a case for rekindling an integrated and normative approach to quality of working life research as one means of promoting workers’ well-being and emancipation. We outline an updated classification of the characteristics of quality of working life and a related analytic framework. We illustrate how research and practice will benefit from following this renewed quality of working life framework, using work design as an example. Concluding, we aim to stimulate debate on the necessity and benefits of rebuilding a quality of working life agenda for marrying academic rigour and practical relevance in order to support interventions aimed at fostering worker emancipation and well-being.