Non-classical β-carbonic anhydrase inhibitors-towards novel anti-mycobacterials

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von Gnielinski, Natascha
Nienaber, Lisa
Mason, Lyndel
Ellis, Samantha
Triccas, James A
Davis, Rohan A
Hofmann, Andreas
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2014
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Abstract

Mycobacterial carbonic anhydrases, such as the essential protein Rv3588c, are attractive drug targets since they constitute a different class of carbonic anhydrases than those found in humans. A natural product library has been screened for compounds that inhibit mycobacterial carbonic anhydrases but lack the much-exploited sulfonamide/sulfamate group. The identified inhibitors of mycobacterial Rv3588c are likely to affect the enzyme at a site different from the catalytic centre - a concept which may be exploited for novel specific anti-mycobacterials.

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MedChemComm

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© 2014 Royal Society of Chemistry. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.

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Medicinal and biomolecular chemistry

Organic chemistry

Medical bacteriology

Pharmacology and pharmaceutical sciences

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