Virtual microscopy is a method by which real-time microscopic illustrations get transmitted digitally via computer networks. There is increasing evidence to suggest that virtual microscopy combined with other didactic methods in teaching make significant improvements in student interaction and curiosity in histopathology and haematology teaching. The introduction of virtual microscopy has opened up a big arena in the field of e-learning in histopathology and haematology curriculum. Case studies prove the technological benefits of virtual microscopy in interacting off-campus students and educators. Recent technological advances have improved the use of virtual microscopy and enabled them to complement students learning in class room as well as for routine diagnostics. In this chapter, the authors discuss the significance, usefulness, and limitations of virtual microscopy in education. In addition, the chapter has provided several technical considerations to develop a friendly web-based virtual microscopy tool in teaching.