Serum podocalyxin for early detection of preeclampsia at 11-13 weeks of gestation

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Mansilla, Mary
Wang, Yao
Hyett, Jonathan
Costa, Fabricio da Silva
Nie, Guiying
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2018
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Abstract

Podocalyxin is expressed on endothelial surface throughout the body and is likely released into the circulation during pregnancy in association with vessel remodeling. We have recently reported that serum podocalyxin is significantly increased in preeclampsia at disease presentation. In this study we investigated whether serum podocalyxin is altered prior to clinical presentation of preeclampsia. At 11–13 weeks of gestation, serum podocalyxin was significantly elevated in women who subsequently developed preeclampsia. Multi-factorial analysis suggests that combination of serum podocalyxin with the long isoform of HtrA3 and mean arterial pressure, may provide effective detection of late-onset preeclampsia at 11–13 weeks of pregnancy.

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Placenta
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71
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Biochemistry and cell biology
Clinical sciences
Science & Technology
Life Sciences & Biomedicine
Developmental Biology
Obstetrics & Gynecology
Reproductive Biology
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Mansilla, M; Wang, Y; Hyett, J; Costa, FDS; Nie, G, Serum podocalyxin for early detection of preeclampsia at 11-13 weeks of gestation, Placenta, 2018, 71, pp. 13-15
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