Chirality has been one of the core research topics in the multidisciplinary fields of materials science, chemistry, biology, medicine, and physics. The subject of chirality in nanomaterials represents one of the most dynamic areas, and it has recently emerged as a new “growth point” of nanoscience. Of particular interest, recent advances in chiral materials endow the asymmetry‐breaking capability to synthesize chiral materials with tunable and reconfigurable chiroptical properties, as well as various functions and emerging applications. Breakthroughs and technological developments have led to the study of many interesting properties of chiral nanocrystals, and some have demonstrated realistic potential, and may address key challenges at the heart of physical sciences. It is timely and necessary to organize a special issue to comprehensively review the state‐of‐the‐art development of chiral materials and future research topics.