Synthesis of a novel pentasaccharide core component from the lipooligosaccharide of Moraxella catarrhalis

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Pearson, Andrew G
Peak, Ian R
Wilson, Jennifer C
Grice, I Darren
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2011
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Abstract

The novel pentasaccharide [p-(trifluoroacetamido)phenyl]ethyl 3-O-b-D-glucopyranosyl-4-O-b-D-glucopyranosyl-6-O-[2-O-(a-D-glucopyranosyl)-b-D-glucopyranosyl]-a-D-glucopyranoside (1), which includes a linker moiety to enable facile coupling to an antigenic protein, was synthesised as a component of a potential vaccine candidate against the Gram-negative bacterium Moraxella catarrhalis. This microorganism is one of three principal causative agents of otitis media in children. The pentasaccharide represents a common cross-serotype (A, B and C) structure from the lipooligosaccharides of Moraxella catarrhalis.

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Carbohydrate Research

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346

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17

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Medicinal and biomolecular chemistry

Medicinal and biomolecular chemistry not elsewhere classified

Organic chemistry

Organic chemistry not elsewhere classified

Biochemistry and cell biology

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