Regioselective Reduction of 3-Methoxymaleimides: an Efficient Method for the Synthesis of Methyl 5-Hydroxytetramates

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Issa, Fatiah
Fischer, Joshua
Turner, Peter
Coster, Mark J
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2006
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Abstract

3-Methoxymaleimide and various N-alkyl-3-methoxymaleimides, synthesized by base-promoted N-alkylation of 3-methoxymaleimide, were reduced using sodium borohydride with complete regioselectivity. The resultant methyl 5-hydroxytetramates are useful intermediates in the synthesis of a variety of tetramate derivatives.

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Journal of Organic Chemistry

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71

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12

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© 2006 American Chemical Society. Self-archiving of the author-manuscript version is not yet supported by this publisher. The contents of this journal can be freely accessed online via the ACS web page [? months] after publication. Use hypertext link above to access the ACS website.

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Medicinal and biomolecular chemistry

Organic chemistry

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