Inhibition of Interleukin 1β Signaling by Anakinra Ameliorates Proinflammatory Cytokine Responses in Zika Virus–Infected Human Blood-Brain Barrier Endothelial Cells (Letter)
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Grau, Georges E
Mahalingam, Suresh
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Abstract
TO THE EDITOR—A recent study by He et al found that interleukin 1β (IL-1β) production during Zika virus (ZIKV) infection was driven by NLRP3 inflammasome activation [1]. NLRP3 activation was mediated by ZIKV nonstructural protein 5 (NS5), leading to IL-1β activation in a process also involving reactive oxygen species. This important study provides new insights into the role of IL-1β signaling in the pathogenesis of ZIKV disease and highlights a new avenue for therapeutic options.
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The Journal of Infectious Diseases
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220
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9
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APP1079086
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Biological sciences
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Hueston, L; Grau, GE; Mahalingam, S, Inhibition of Interleukin 1β Signaling by Anakinra Ameliorates Proinflammatory Cytokine Responses in Zika Virus–Infected Human Blood-Brain Barrier Endothelial Cells (Letter), The Journal of Infectious Diseases, 2019, 220 (9), pp. 1539-1540