Synthesis and active manipulation of magnetic liquid beads
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Galogahi, Fariba Malekpour
Vashi, Aditya
Tran, Du Tuan
Kijanka, Gregor S
Cha, Haotian
Sreejith, Kamalalayam Rajan
Nguyen, Nam-Trung
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Abstract
We report the fabrication and characterisation of magnetic liquid beads with a solid magnetic shell and liquid core using microfluidic techniques. The liquid beads consist of a fluorinated oil core and a polymer shell with magnetite particles. The beads are generated in a flow-focusing polydimethylsiloxane (PDMS) device and cured by photo polymerisation. We investigated the response of the liquid beads to an external magnetic field by characterising their motion towards a permanent magnet. Magnetic sorting of liquid beads in a channel was achieved with 90% efficiency. The results show that the liquid beads can be controlled magnetically and have potential applications in digital microfluidics including nucleic acid amplification, drug delivery, cell culture, sensing, and tissue engineering. The present paper also discusses the magnetophoretic behaviour of the liquid bead by varying its mass and magnetite concentration in the shell. We also demonstrated the two-dimensional self-assembly of magnetic liquid beads for potential use in digital polymerase chain reaction and digital loop mediated isothermal amplification. Graphical abstract: (Figure presented.)
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Biomedical Microdevices
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26
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2
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DP220100261
FL230100023
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© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/
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Biomedical engineering
Nanotechnology
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Yadav, AS; Galogahi, FM; Vashi, A; Tran, DT; Kijanka, GS; Cha, H; Sreejith, KR; Nguyen, N-T, Synthesis and active manipulation of magnetic liquid beads, Biomedical Microdevices, 2024, 26 (2), pp. 24