Analysis of repetitive element expression in the blood and skin of patients with Parkinson's disease identifies differential expression of satellite elements
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Lattekivi, Freddy
Planken, Anu
Reimann, Ene
Kurvits, Lille
Kadastik-Eerme, Liis
Kasterpalu, Kristjan M
Bubb, Vivien J
Quinn, John P
Koks, Sulev
Taba, Pille
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Abstract
Repetitive elements (RE) constitute the majority of the human genome and have a range of functions both structural and regulatory on genomic function and gene expression. RE overexpression has been observed in several neurodegenerative diseases, consistent with the observation of aberrant expression of RE posing a mutagenic threat. Despite reports that associate RE expression with PD no study has comprehensively analysed the role of these elements in the disease. This study presents the first genome-wide analysis of RE expression in PD to date. Analysis of RNA-sequencing data of 12 PD patients and 12 healthy controls identified tissue-specific expression differences and more significantly, differential expression of four satellite elements; two simple satellite III (repName = CATTC_n and _GAATG_n) a high-copy satellite II (HSATII) and a centromeric satellite (ALR_Alpha) in the blood of PD patients. In support of the growing body of recent evidence associating REs with neurodegenerative disease, this study highlights the potential importance of characterization of RE expression in such diseases.
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Scientific Reports
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9
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© The Author(s) 2019. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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Neurology and neuromuscular diseases
Clinical sciences
Medical genetics (excl. cancer genetics)
Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
GENE-EXPRESSION
RETROTRANSPOSITION
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Billingsley, KJ; Lattekivi, F; Planken, A; Reimann, E; Kurvits, L; Kadastik-Eerme, L; Kasterpalu, KM; Bubb, VJ; Quinn, JP; Koks, S; Taba, P, Analysis of repetitive element expression in the blood and skin of patients with Parkinson's disease identifies differential expression of satellite elements, Scientific Reports, 2019, 9