Chiral gold nanoparticles enantioselectively rescue memory deficits in a mouse model of Alzheimer's disease

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Hou, Ke
Zhao, Jing
Wang, Hui
Li, Bin
Li, Kexin
Shi, Xinghua
Wan, Kaiwei
Ai, Jing
Lv, Jiawei
Wang, Dawei
Huang, Qunxing
Wang, Huayi
Cao, Qin
Liu, Shaoqin
Tang, Zhiyong
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2020
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http://creativecommons.org/licenses/by/4.0/
Abstract

Preventing aggregation of amyloid beta (Aβ) peptides is a promising strategy for the treatment of Alzheimer’s disease (AD), and gold nanoparticles have previously been explored as a potential anti-Aβ therapeutics. Here we design and prepare 3.3 nm L- and D-glutathione stabilized gold nanoparticles (denoted as L3.3 and D3.3, respectively). Both chiral nanoparticles are able to inhibit aggregation of Aβ42 and cross the blood-brain barrier (BBB) following intravenous administration without noticeable toxicity. D3.3 possesses a larger binding affinity to Aβ42 and higher brain biodistribution compared with its enantiomer L3.3, giving rise to stronger inhibition of Aβ42 fibrillation and better rescue of behavioral impairments in AD model mice. This conjugation of a small nanoparticle with chiral recognition moiety provides a potential therapeutic approach for AD.

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Nature Communications
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11
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1
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© The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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Biological sciences
Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
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Hou, K; Zhao, J; Wang, H; Li, B; Li, K; Shi, X; Wan, K; Ai, J; Lv, J; Wang, D; Huang, Q; Wang, H; Cao, Q; Liu, S; Tang, Z, Chiral gold nanoparticles enantioselectively rescue memory deficits in a mouse model of Alzheimer's disease, Nature Communications, 2020, 11 (1), pp. 4790
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