Compartmental modeling of skin absorption and desorption kinetics: Donor solvent evaporation, variable diffusion/partition coefficients, and slow equilibration process within stratum corneum

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Amarah, AA
Hadgraft, J
Roberts, MS
Anissimov, YG
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2022
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Abstract

This work expands the recently developed compartmental model for skin transport to model variable diffusion and/or partition coefficients, and the presence of slow equilibration/slow binding kinetics within stratum corneum. The model was validated by comparing it with the diffusion model which was solved numerically using the finite element method. It was found that the new compartmental model predictions agreed well with that of the diffusion model, providing a sufficient number of compartments was used. The compartmental model was applied to two previously published experimental data sets: water penetration and desorption data and the finite dose dermal penetration of testosterone. Significant improvement of the fitting quality for all these data sets was achieved using the compartmental model.

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International Journal of Pharmaceutics
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623
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Pharmacology and pharmaceutical sciences
Science & Technology
Life Sciences & Biomedicine
Pharmacology & Pharmacy
Skin transport
Compartmental model
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Amarah, AA; Hadgraft, J; Roberts, MS; Anissimov, YG, Compartmental modeling of skin absorption and desorption kinetics: Donor solvent evaporation, variable diffusion/partition coefficients, and slow equilibration process within stratum corneum, International Journal of Pharmaceutics, 2022, 623, pp. 121902
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