Dysidenin from the Marine Sponge Citronia sp. Affects the Motility and Morphology of Haemonchus contortus Larvae In Vitro
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Taki, Aya C
Lum, Kah Yean
Hayes, Sasha
Byrne, Joseph J
Wang, Tao
Hofmann, Andreas
Ekins, Merrick G
White, Jonathan M
Jabbar, Abdul
Davis, Rohan A
Gasser, Robin B
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Abstract
High-throughput screening of the NatureBank marine extract library (n = 7616) using a phenotypic assay for the parasitic nematode Haemonchus contortus identified an active extract derived from the Australian marine sponge Citronia sp. Bioassay-guided fractionation of the CH2Cl2/MeOH extract from Citronia sp. resulted in the purification of two known hexachlorinated peptides, dysidenin (1) and dysideathiazole (2). Compound 1 inhibited the growth/development of H. contortus larvae and induced multiple phenotypic changes, including a lethal evisceration (Evi) phenotype and/or somatic cell and tissue destruction. This is the first report of anthelmintic activity for these rare and unique polychlorinated peptides.
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Marine Drugs
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19
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12
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© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Pharmacology and pharmaceutical sciences
Physical chemistry
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Ramage, KS; Taki, AC; Lum, KY; Hayes, S; Byrne, JJ; Wang, T; Hofmann, A; Ekins, MG; White, JM; Jabbar, A; Davis, RA; Gasser, RB, Dysidenin from the Marine Sponge Citronia sp. Affects the Motility and Morphology of Haemonchus contortus Larvae In Vitro, Marine Drugs, 19 (12), pp. 698-698