Relative abundance of full-length and truncated FOXP1 isoforms is associated with differential NFκB activity in Follicular Lymphoma
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Gandhi, Maher
Courtney, Mark
Marlton, Paula
Griffiths, Lyn
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Abstract
FOXP1 is a transcriptional repressor that has been proposed to repress the expression of some NFkBresponsive genes. Furthermore, truncated forms of FOXP1 have been associated with a subtype of Diffuse Large B-cell Lymphoma characterised by constitutive NF-B activity, indicating that they may inhibit this repression. We have shown that FL tumors have increased relative abundance of truncated FOXP1 isoforms and this is associated with increased expression of NFkB-associated genes. Our results provide strong evidence that relative FOXP1 isoform abundance is associated with NFkB activity in FL, and could potentially be used as a marker for this gene signature.
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Leukemia Research
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33
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12
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© 2009 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
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Subject
Gene expression (incl. microarray and other genome-wide approaches)
Clinical sciences
Cardiovascular medicine and haematology