Smart Nanotheranostics Responsive to Pathological Stimuli
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Rudzinska, M
Leporatti, S
Anissimov, Y
Zamyatnin, AA
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Abstract
The development of nanotheranostics represents one of the most dynamic technological frontiers in the treatment of different pathological conditions. With the goal in mind to generate nanocarriers with both therapeutic and diagnostic properties, current research aims at implementing these technologies with multiple functions, including targeting, multimodal imaging, and synergistic therapies. The working mechanism of some nanotheranostics relies on physical, chemical, and biological triggers allowing for the activation of the therapeutic and/or the diagnostic properties only at the diseased site. In this review, we explored new advances in the development of smart nanotheranostics responsive to pathological stimuli, including altered pH, oxidative stress, enzymatic expression, and reactive biological molecules with a deep focus on the material used in the field to generate the particles in the context of the analyzed disease.
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Frontiers in Bioengineering and Biotechnology
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8
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© 2020 Parodi, Rudzinska, Leporatti, Anissimov and Zamyatnin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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Other biological sciences
Biomedical engineering
Medical biotechnology
Nanotechnology
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Parodi, A; Rudzinska, M; Leporatti, S; Anissimov, Y; Zamyatnin, AA, Smart Nanotheranostics Responsive to Pathological Stimuli, Frontiers in Bioengineering and Biotechnology, 2020, 8, pp. 503