Dairy Intake and Parkinson's Disease: A Mendelian Randomization Study

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Domenighetti, Cloe
Sugier, Pierre-Emmanuel
Sreelatha, Ashwin Ashok Kumar
Schulte, Claudia
Grover, Sandeep
Mohamed, Oceane
Portugal, Berta
May, Patrick
Bobbili, Dheeraj R
Radivojkov-Blagojevic, Milena
Lichtner, Peter
Singleton, Andrew B
Hernandez, Dena G
Edsall, Connor
Mellick, George D
et al.
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2022
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Abstract

Background: Previous prospective studies highlighted dairy intake as a risk factor for Parkinson's disease (PD), particularly in men. It is unclear whether this association is causal or explained by reverse causation or confounding. Objective: The aim is to examine the association between genetically predicted dairy intake and PD using two-sample Mendelian randomization (MR). Methods: We genotyped a well-established instrumental variable for dairy intake located in the lactase gene (rs4988235) within the Courage-PD consortium (23 studies; 9823 patients and 8376 controls of European ancestry). Results: Based on a dominant model, there was an association between genetic predisposition toward higher dairy intake and PD (odds ratio [OR] per one serving per day = 1.70, 95% confidence interval = 1.12–2.60, P = 0.013) that was restricted to men (OR = 2.50 [1.37–4.56], P = 0.003; P-difference with women = 0.029). Conclusions: Using MR, our findings provide further support for a causal relationship between dairy intake and higher PD risk, not biased by confounding or reverse causation. Further studies are needed to elucidate the underlying mechanisms. © 2022 International Parkinson and Movement Disorder Society.

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Movement Disorders
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37
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4
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Science & Technology
Life Sciences & Biomedicine
Clinical Neurology
Neurosciences & Neurology
dairy intake
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Domenighetti, C; Sugier, P-E; Sreelatha, AAK; Schulte, C; Grover, S; Mohamed, O; Portugal, B; May, P; Bobbili, DR; Radivojkov-Blagojevic, M; Lichtner, P; Singleton, AB; Hernandez, DG; Edsall, C; Mellick, GD et al., A, Dairy Intake and Parkinson's Disease: A Mendelian Randomization Study, Movement Disorders, 2022, 37 (4), pp. 857-864
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