Patient and healthcare professionals preference for Brenzys vs. Enbrel autoinjector for rheumatoid arthritis: A randomized crossover simulated-use study

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Egeth, Marc
Soosaar, Jennifer
Nash, Peter
Choquette, Denis
Infante, Ricardo
Ramey, Dena Rosen
Sahakian, Sevag
Lai, Angela
Kim, Jin Ju
Wu, David
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2017
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https://creativecommons.org/licenses/by/4.0
Abstract

Introduction: Brenzys was developed as an etanercept biosimilar of Enbrel. The aim of this study was to assess preference and perceived ease of use for the new Brenzys autoinjector compared to the currently available marketed Enbrel MYCLIC autoinjector (Australia) and Enbrel SureClick autoinjector (Canada) for the treatment of rheumatoid arthritis (RA). Because RA affects manual dexterity, ease of use of an autoinjector is a particularly important consideration in developing effective self-delivery of long-term courses of therapy. Methods: Patients (N = 191) reporting a diagnosis of RA and nurses and rheumatologists (N = 90) with experience managing RA were shown how to use Brenzys and Enbrel autoinjectors (in counterbalanced order between participants), then they used each autoinjector by injecting into a pad simulating skin, and completed a questionnaire. Study sessions took place in Australia and Canada. Results: A binomial test showed that significantly more patients indicated that the Brenzys autoinjector was easier to use than the Enbrel autoinjector (79% reporting Brenzys easier to use; p < 0.001, two-sided, 95% CI [73%, 85%]). In addition, significantly more nurses and rheumatologists with experience managing RA also indicated that the Brenzys autoinjector was easier to use (86%; p < 0.001, two-sided, 95% CI [77%, 92%) and that they would recommend the buttonless Brenzys autoinjector over the Enbrel autoinjector to patients (83%; p < 0.001, two-sided, 95% CI [74%, 90%]). Almost all patients who reported past experience using an Enbrel autoinjector (N = 17) reported on the basis of using the two devices in the study that they would prefer to switch their device to the Brenzys autoinjector rather than continue their course of therapy using the Enbrel autoinjector (16/17, 94%, 95% CI [71%, 100%]). Conclusion: On the basis of the study results, the Brenzys autoinjector was rated statistically significantly easier to use, and was overall preferred by patients and healthcare professionals with experience managing RA patients. Funding: Merck & Co., Inc.

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Advances in Therapy
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34
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5
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© The Author(s) 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0), which permits use, duplication, adaptation, distribution, and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
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Pharmacology and pharmaceutical sciences
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Life Sciences & Biomedicine
Medicine, Research & Experimental
Pharmacology & Pharmacy
Research & Experimental Medicine
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Egeth, M; Soosaar, J; Nash, P; Choquette, D; Infante, R; Ramey, DR; Sahakian, S; Lai, A; Kim, JJ; Wu, D, Patient and healthcare professionals preference for Brenzys vs. Enbrel autoinjector for rheumatoid arthritis: A randomized crossover simulated-use study, Advances in Therapy, 2017, 34 (5), pp. 1157-1172