Assessing the impacts of climate change and land-use change is of critical importance, particularly for urbanized catchments. In this study, a novel framework was used to examine and quantify these impacts on the runoff in six catchments in Southeast Queensland, Australia. For each catchment, temporal variations in impervious areas were derived from six satellite images using a sub-pixel classification technique and incorporated into the SIMHYD hydrological model. This model was satisfactorily calibrated and validated with daily runoff observations (0.63 ≤ Nash–Sutcliffe efficiency coefficient ≤ 0.94, percent bias ≤ ±18 %) and was used to produce baseline runoff for 1986–2005 in these six catchments. The projected population increase was used to predict future imperviousness based on the linear relationship between the two. The projected rainfall and evapotranspiration were derived from the ensemble means of the eight general circulation models. Catchment runoff was projected under two climate change scenarios (RCP4.5 and 8.5), three urbanization scenarios (low, medium, and high), and six combined scenarios for two future periods (2026–2045 and 2046–2065). Comparing with the baseline, it was found that (1) climate change alone would lead to a −3.8 % to −17.6 % reduction in runoff among the six catchments, for all scenarios and both future periods; (2) a 11.8 % to 78 % increase in runoff was projected under the three urbanization scenarios, and (3) a decrease in runoff due to climate change would moderate the increase in runoff caused by urbanization. For example, the combined effect would be a 54 % increase in runoff, with a −17.2 % decrease due to climate change and 78 % increase due to urbanization. Overall, runoff in the six catchments may be significantly affected by urban expansion. From this study, decision makers could gain a better understanding of the relative importance of the effects of climate and land-use change, which can be applied when developing future long-term water management plans at the catchment scale.