The Design, Synthesis and Assessment of Novel Haemagglutinin- Neuraminadase Inhibitors

Loading...
Thumbnail Image
File version
Primary Supervisor
Itzstein, Mark von
Other Supervisors
Dyason, Jeff
Thomson, Robin
Editor(s)
Date
2007
Size
File type(s)
Location
License
Abstract

The human parainfluenza viruses (hPIV) are leading causes of respiratory disease in young children, the immunocompromised and the elderly. All subtypes can cause lower and upper respiratory disease. The surface of human parainfluenzza virus and a number of other paramyxoviruses contains, amongst other biomolecules, a multifunctional glycoprotein known as haemagglutinin-neuraminidase (HN). The HN has three roles in viral pathogenesis; the binding to terminally bound sialic acid residues of cell oligosaccharides, thereby mediating viral attacment to the host cell; the promotion of viral and host cell fusion; and the cleavage of cell surface sialic acids to promote viral elution from host cells. The important role of HN in the viral life-cycle makes it an attractive target for therapeutic intervention. This thesis details an investigation into the design, synthesis and assessment of novel inhibitors of paramyxoviral haemagglutinin-neuraminidase.

Journal Title
Conference Title
Book Title
Edition
Volume
Issue
Thesis Type
Thesis (PhD Doctorate)
Degree Program
Doctor of Philosophy (PhD)
School
Institute for Glycomics
Publisher link
Patent number
Funder(s)
Grant identifier(s)
Rights Statement
Rights Statement
The author owns the copyright in this thesis, unless stated otherwise.
Item Access Status
Public
Note
This thesis has been scanned.
Access the data
Related item(s)
Subject
Human parainfluenza viruses
Respiratory disease
Cell oligosaccharides
Haemagglutinin-neuraminidase
Persistent link to this record
Citation