Discovery of α,β- and α,γ-diamino acid scaffolds for the inhibition of M1 family aminopeptidases
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Gumpena, Rajesh
Kishor, Chandan
Ganji, Roopa Jones
Addlagatta, Anthony
Kishor, Chandan
Ganji, Roopa Jones
Addlagatta, Anthony
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2011
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Abstract
Flipping out! The X-ray crystal structure of L-α,γ-diaminobutyric acid (DABA, shown in magenta) in complex with an M1 family aminopeptidase reveals that the γ-amino group displaces the α-amino group from its original position (as in the complex with lysine, shown in cyan), which in turn results in a peptide flip at Met 260.
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ChemMedChem
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6
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11
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Medicinal and Biomolecular Chemistry not elsewhere classified
Medicinal and Biomolecular Chemistry
Organic Chemistry
Pharmacology and Pharmaceutical Sciences