AIM: To determine factors correlated with postoperative radial shortening in patients with distal radius fractures treated with volar locking distal radius plates. METHODS: A total of 250 patients with a distal radius fracture stabilised with volar locking plates between January 2010 and December 2014 were included in a multicentre retrospective cohort study. We measured the distance of the distal locking screws to the joint line immediately postoperatively and then measured radial shortening after six to eight weeks using the change in ulnar variance. RESULTS: Multivariate linear regression analysis showed that there was a significant linear association between the distance of the screws from the joint line and radial shortening. No other patient, injury, or treatment-related characteristic significantly influenced radial shortening in multivariate analysis. CONCLUSION: Distal locking screws should be placed as close as possible to the subchondral joint line to prevent postoperative loss of reduction.