Economic Evaluation of Reproductive Carrier Screening for Recessive Genetic Conditions: A Systematic Review

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Wang, Tianjiao
Bahrampour, Mina
Byrnes, Joshua
Scuffham, Paul
Kirk, Edwin
Downes, Martin
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2021
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Abstract

INTRODUCTION: Autosomal recessive (AR) and x-linked (XL) conditions are rare but collectively common which impact millions of people globally on morbidity, mortality and costs. Advanced medical technologies allow prospective parents to make informed reproductive decisions to avoid having affected children. Economic evaluations targeting on reproductive carrier screening (RCS) for AR and/or XL conditions have been conducted, but there has not been a systematic review in this area. AREAS COVERED: A systematic search of economic evaluations for RCS was undertaken using the following databases - EMBASE, MEDLINE and SCOPUS. The search strategy was designed to capture full economic evaluations related to RCS since 1990. This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) strategy. The included 23 studies adopted various types of methodologies to conduct economic evaluations. The majority of studies examined a single condition. The various clinical strategies and screened conditions caused the different cost-effectiveness conclusions in the published studies. EXPERT OPINION: Establishing a validated and practical clinical strategy of RCS and investigating the cost-effectiveness of multiple conditions in one economic evaluation are critical for implementing RCS in the future. Further economic evaluations are essential to provide evidence-based practice for decision-makers.

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Expert Review of Pharmacoeconomics & Outcomes Research

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This is an Author's Accepted Manuscript of an article published in the Expert Review of Pharmacoeconomics & Outcomes Research, 13 Oct 2021, copyright Informa UK Limited, trading as Taylor & Francis Group, available online at: https://doi.org/10.1080/14737167.2022.1993063

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This publication has been entered in Griffith Research Online as an advanced online version.

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Health economics

Pharmacology and pharmaceutical sciences

Applied economics

X-linked

autosomal recessive

economic evaluation

reproductive carrier screening

systematic review

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Wang, T; Bahrampour, M; Byrnes, J; Scuffham, P; Kirk, E; Downes, M, Economic Evaluation of Reproductive Carrier Screening for Recessive Genetic Conditions: A Systematic Review, Expert Review of Pharmacoeconomics & Outcomes Research, 2021

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