Alkaloids from roots of Stemona sessilifolia and their antitussive activities

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Author(s)
Yang, Xin-Zhou
Zhu, Jian-Yu
Tang, Chun-Ping
Ke, Chang-Qiang
Lin, Ge
Cheng, Tin-Yan
A. Rudd, John
Ye, Yang
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2009
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Abstract

Protostemonamide (1), a new protostemonine-type alkaloid, and 12 known compounds were isolated from the roots of Stemona sessilifolia. Their structures were elucidated by 1 D and 2 D NMR spectral and other spectroscopic studies. The main alkaloidal constituents, protostemonine (2), stemospironine (4), and maistemonine (7), showed significant antitussive activity in a citric acid-induced guinea pig cough model following peripheral administration; stemonamine (11) had antitussive activity following i. c. v. administration.

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Planta Medica

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75

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2

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Pharmacology and Pharmaceutical Sciences not elsewhere classified

Plant Biology

Complementary and Alternative Medicine

Pharmacology and Pharmaceutical Sciences

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