This paper explored individual- and system-level factors affecting the provision of care services for rural patients. An integrated literature review across four databases identified 22 studies from six countries. A focus on health and wellbeing and the influence of rurality was explored. Findings indicate physical and functional health in rural cancer patients is lower in comparison with urban areas. Influencing factors were socio-economic status, age, income, health literacy, control and self-efficacy. Enhancing the strengths and education of caregivers and their inclusion in service decision-making are paramount for rural cancer patients and for the wellbeing of the caregivers. Disparities in rural areas need to be explored with longitudinal research to understand the clinical, social and cultural characteristics in relation to remoteness. The use of innovative technologies has been recommended as an option to enhance the health access and enable quality care provision across rural areas.