Synergistic Interactions of the Antiretroviral Protease Inhibitors Saquinavir and Ritonavir with Chloroquine and Mefloquine against Plasmodium falciparum In Vitro
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Skinner-Adams, TS
Andrews, KT
Melville, L
McCarthy, J
Gardiner, DL
Andrews, KT
Melville, L
McCarthy, J
Gardiner, DL
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2007
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Abstract
The antimalarial activity of several antiretroviral protease inhibitor combinations was investigated. Data demonstrate that ritonavir and saquinavir behave synergistically with chloroquine and mefloquine. These data, and interactions with pepstatin-A, E-64, and bestatin, suggest that human immunodeficiency virus protease inhibitors do not target digestive-vacuole plasmepsins.
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Antimicrobial agents and Chemotherapy
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51
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2
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Microbiology
Medical microbiology
Pharmacology and pharmaceutical sciences