Neisseria meningitidis, an exclusive human pathogen, poses a considerable public health threat. Despite the availability of effective antibiotics, and vaccines for serogroups A, B, C, W and Y, N. meningitidis remains a leading cause of bacterial meningitis [1], with mortality rates as high as 10% (owing to the rapid onsets characteristic of the disease) and survivors often endure debilitating sequelae [2]. Furthermore, in light of the fact that changes in serogroup circulation is unpredictable, there remains a need for a broad spectrum vaccine [3]. N. meningitidis expresses numerous adhesins that allow it to interact with diverse microenvironments within the host - from asymptomatic nasopharyngeal colonization of the mucosal epithelia, to invasion and spread within the blood stream and infection of the meninges. On the host side, the receptors involved in these stages of meningococcal infection are not fully elucidated, but are known to involve several carbohydrate structures (glycans). This thesis seeks to fully characterise glycan binding by N. meningitidis.