Previous research into the social consequences of persistent pain has shown that relationship difficulties and marital distress are major factors that contribute to negative outcomes for sufferers. Furthermore, psychological distress is often co-morbid with persistent pain. This study explored the relationship between persistent pain, psychological distress and emotional connectedness. It involved a cross-sectional design utilising an online survey of 388 Australian women with persistent pain. Self-report measures of pain severity, psychological distress and emotional connectedness were administered. Results confirmed that many women in persistent pain experience relationship and emotional connectedness difficulties which they attribute to the experience of persistent pain. Additionally, psychological distress significantly mediated the relationship between pain severity and emotional connectedness. It was concluded that, in this sample of persistent pain sufferers, pain severity and psychological distress had significant impact on a women's ability to connect emotionally to those closest to them. The implications of these findings for intervening with women who suffer with persistent pain are discussed.