We examine the collaborative practices of an interdisciplinary research team working across Cameroon and the United States to study the dynamics of a floodplain fishery as a coupled social-ecological system. Based on three years of survey data following team meetings, we discuss the challenges we encountered and explore the elements that ultimately allowed our heterogeneous scientific practices to “hang together.” We show how it was useful for us to consider different outputs of the project, in particular our integrated numerical model, as snapshots of epistemic processes supporting interdisciplinary exchange rather than purely as research products. We also argue against the pursuit of epistemological consensus within interdisciplinary research teams, and instead for accepting and even supporting multi-epistemological friction, or the messy and creative process of making connections across differences.