Mitocans revisited: Mitochondrial targeting as efficient anti-cancer therapy

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Dong, L
Gopalan, V
Holland, O
Neuzil, J
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2020
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Mitochondria are essential cellular organelles, controlling multiple signalling pathways critical for cell survival and cell death. Increasing evidence suggests that mitochondrial metabolism and functions are indispensable in tumorigenesis and cancer progression, rendering mitochondria and mitochondrial functions as plausible targets for anti-cancer therapeutics. In this review, we summarised the major strategies of selective targeting of mitochondria and their functions to combat cancer, including targeting mitochondrial metabolism, the electron transport chain and tricarboxylic acid cycle, mitochondrial redox signalling pathways, and ROS homeostasis. We highlight that delivering anti-cancer drugs into mitochondria exhibits enormous potential for future cancer therapeutic strategies, with a great advantage of potentially overcoming drug resistance. Mitocans, exemplified by mitochondrially targeted vitamin E succinate and tamoxifen (MitoTam), selectively target cancer cell mitochondria and efficiently kill multiple types of cancer cells by disrupting mitochondrial function, with MitoTam currently undergoing a clinical trial.

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International Journal of Molecular Sciences

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21

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21

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© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Other chemical sciences

Genetics

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Biochemistry and cell biology

Microbiology

Medicinal and biomolecular chemistry

anti-cancer strategy

drug delivery

mitocans

mitochondrial targeting

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Dong, L; Gopalan, V; Holland, O; Neuzil, J, Mitocans revisited: Mitochondrial targeting as efficient anti-cancer therapy, International Journal of Molecular Sciences, 2020, 21 (21), pp. 7941

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