Chirality means the ones that are not superimposable on their mirror images. It is a fantastic phenomenon ubiquitous in nature and the universe. It has always been one of the most important research topics with its profound significance in the origin of life. Recently, with the development of nanoscience and nanotechnology, the construction of chiral nanomaterials with particular chemical, physical and biologic properties got fast development. Here, we will present the general synthesis of all kinds of inorganic and organic chiral nanomaterials.