MAIA, Fc receptor-like 3, supersedes JUNO as IZUMO1 receptor during human fertilization
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Frolikova, Michaela
Ded, Lukas
Cerny, Jiri
Postlerova, Pavla
Palenikova, Veronika
Simonik, Ondrej
Nahacka, Zuzana
Basus, Krystof
Valaskova, Eliska
Machan, Radek
Pacey, Allan
Holubcova, Zuzana
Koubek, Pavel
Neuzil, Jiri
et al.
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Abstract
Gamete fusion is a critical event of mammalian fertilization. A random one-bead one-compound combinatorial peptide library represented synthetic human egg mimics and identified a previously unidentified ligand as Fc receptor-like 3, named MAIA after the mythological goddess intertwined with JUNO. This immunoglobulin super family receptor was expressed on human oolemma and played a major role during sperm-egg adhesion and fusion. MAIA forms a highly stable interaction with the known IZUMO1/JUNO sperm-egg complex, permitting specific gamete fusion. The complexity of the MAIA isotype may offer a cryptic sexual selection mechanism to avoid genetic incompatibility and achieve favorable fitness outcomes.
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Science Advances
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8
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36
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© 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).
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Fertility
Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
SPERM
PROTEIN
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Vondrakova, J; Frolikova, M; Ded, L; Cerny, J; Postlerova, P; Palenikova, V; Simonik, O; Nahacka, Z; Basus, K; Valaskova, E; Machan, R; Pacey, A; Holubcova, Z; Koubek, P; Neuzil, J; et al., MAIA, Fc receptor-like 3, supersedes JUNO as IZUMO1 receptor during human fertilization, Science Advances, 2022, 8 (36), pp. eabn0047