Rejection sensitivity (RS) instigates conflict and prompts maladaptive conflict responses within romantic relationships. We tested whether RS had similar effects within friendships (N = 262, X age = 11.7) by investigating whether (a) RS was associated with more frequent conflict, (b) two RS forms prompted different conflict responses, and (c) conflict and responses mediated associations of RS with friendship instability. Adolescents higher in angry RS reported more frequent conflict, more anger and aggression, and less compromise. Anxious RS was not uniquely associated with conflict, but heightened anxious RS was associated with more obliging and compromise, less aggression, and greater friendship instability. Thus, adolescents with heightened angry and anxious RS reported different patterns of maladaptive conflict responses, but only angry RS was uniquely associated with more frequent conflict and only anxious RS was uniquely associated with greater friendship instability. The mediational model of friendship instability was not supported.