Personalized nutrition is an approach that is currently attracting increasing interest in the area of sport and exercise. The prospect of individually tailored, and therefore more effective, sport and exercise nutrition sounds appealing, but research in this area is still in its infancy. To compliment traditional analysis of group mean response, studies are trying to describe the totality of responses by providing individual performance and health data to an intervention which often show large inter-individual variability. Emerging evidence indicates that sport nutrition strategies may work in some individuals or under certain conditions, yet not in others, likely due to a myriad of environmental and genetic factors, highlighting the necessity in providing a more thorough examination of results. The current Research Topic aimed to provide a platform for original data and reviews on novel strategies for personalized sport and exercise nutrition.