Guttiferones O and P, Prenylated Benzophenone MAPKAPK-2 Inhibitors from Garcinia solomonensis
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Suraweera, Lekha
King, Gordon
Rali, Topul
Quinn, Ronald J
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Abstract
Two prenylated benzophenones, guttiferones O (1) and P (2), were isolated from the stem bark of the Papua New Guinean plant Garcina solomonensis. The structures of these compounds and their relative con?gurations were determined by spectroscopic methods. Both compounds inhibited the phosphorylation of the synthetic biotinylated peptide substrate KKLNRTLSVA by the serine/threonine protein kinase MAPKAPK-2 with IC50 values of 22.0 卮
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Journal of Natural Products
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72
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9
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© 2009 American Chemical Society. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please refer to the journal link for access to the definitive, published version or contact the author[s] for more information.
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Chemical sciences
Biological sciences
Biomedical and clinical sciences
Traditional, complementary and integrative medicine