CD4+ T cells reduce the tissue burden of Chlamydia muridarum in male BALB/c mice

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A. Cunningham, Kelly
J. Carey, Alison
Timms, Peter
W. Beagley, Kenneth
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2010
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Abstract

Male chlamydial infections are becoming more recognised as an aetiological agent in infertility. An IFN-? response is required for protection against Chlamydia in females, but may have the potential to induce pathology in the immune-privileged male reproductive tract. We examined the induction of immunity following intranasal immunisation with major outer membrane protein (MOMP) of Chlamydia muridarum in male BALB/c mice, and the role of MOMP-specific CD4+ T cells in clearance of an intrapenile infection. Here we report that adoptive transfer of MOMP-specific CD4+ T cells into naﶥ mice confers partial protective immunity, which significantly reduces the tissue burden of Chlamydia.

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Vaccine

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28

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31

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© 2010 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.

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Immunology not elsewhere classified

Biological Sciences

Agricultural and Veterinary Sciences

Medical and Health Sciences

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