[18F]GE-180 PET/CT assessment of enterocytic translocator protein (TSPO) over-expression: a pilot study in gastrointestinal GVHD
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Thomas, Paul
Pattison, David A
Francis, Leo
Ridge, Paula
Tey, Siok-Keen
Kennedy, Glen A
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Abstract
Diagnostic endoscopy for suspected acute gastrointestinal graft-versus-host disease (GI-GVHD) is limited by procedural risk, GI tract length and patchy histological involvement. Consequently, up to one quarter of GI-GVHD cases lack histological confirmation [1], with implications for treatment and prognostication. Positron emission tomography combined with computed tomography (PET/CT) assessment of the entire GI tract could overcome the shortcomings of endoscopy but is limited by a lack of specificity of the 18-fluoro-deoxyglucose ([18F]FDG) radiotracer [2, 3].
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Bone Marrow Transplantation
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57
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3
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Scott, AP; Thomas, P; Pattison, DA; Francis, L; Ridge, P; Tey, S-K; Kennedy, GA, [F-18]GE-180 PET/CT assessment of enterocytic translocator protein (TSPO) over-expression: a pilot study in gastrointestinal GVHD, Bone Marrow Transplantation, 2022, 57 (3), pp. 517-519