The SARS-CoV2 - ACE2 link: A physiopathological analysis
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Andry, C
Burks, EJ
Hamlet, S
Janssen, EAM
Kjellevold, KH
de Las Morenas, A
Miller, NS
Miroiu, RI
Nusem, I
Popa-Wagner, A
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Abstract
The Covid-19 pandemic represents an unsolved problem which has caused numerous fatalities. At the present time, there is no vaccination available or curative therapy. However, recent reports suggest that SARS-CoV2 acts upon its functional receptor ACE2 inducing a variety of deleterious effects such as inflammation, endothelial dysfunction, microangiopathy, myocarditis, thrombosis and myocardial infarction. The details of the SARS-CoV2 -ACE2 interaction are poorly understood and most of the hypothesis related to this are based on the extrapolation of previous research focusing on ACE2 as a receptor for SARS-CoV. Considering the similarities between SARS-CoV2 and SARS-CoV we have conducted e physiopathological analysis focusing on the key pathogenic role of ACE2 as a functional receptor for SARS-CoV2. In this context, we have identified several potential therapeutic targets which should be further evaluated in patients with Covid-19. It is likely that an efficient therapy for Covid-19 will be revealed by research investigating the binding of viral spike S protein to ACE2, and the immunological response determined by SARS-CoV2-ACE2 interaction, including the anti-viral role of plasmacytoid dendritic cells and anti-inflammatory reprogramming of macrophages.
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Vascular Cell
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12
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1
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© Eugen B Petcu, Christopher Andry, Eric J Burks, Stephen Hamlet, Emiel AM Janssen, Kjell H Kjellevold, Antonio de Las Morenas, Nancy S Miller, Rodica I Miroiu, Iulian Nusem, Aurel Popa-Wagner. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (https://creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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Biochemistry and cell biology
Cardiovascular medicine and haematology
Oncology and carcinogenesis
Bioinformatics and computational biology
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Petcu, EB; Andry, C; Burks, EJ; Hamlet, S; Janssen, EAM; Kjellevold, KH; de Las Morenas, A; Miller, NS; Miroiu, RI; Nusem, I; Popa-Wagner, A, The SARS-CoV2 - ACE2 link: A physiopathological analysis, Vascular Cell, 2020, 12 (1), pp. 5