Earthquake‐induced building collapse and progressive collapse due to accidental local failure of vertical components are the two most common failure modes of reinforced concrete (RC) frame structures. Conventional design methods usually focus on the design requirements of a specific hazard but neglect the interactions between different designs. For example, the progressive collapse design of an RC frame often yields increased reinforcement and flexural strength of the beams. As a result, the seismic design principle of “strong‐column‐weak‐beam” may be violated, which may lead to unfavorable failure modes and weaken the seismic performance. To avoid these adverse effects of the progressive collapse design on the seismic resistance of RC frames, a novel structural detailing is proposed in this study. The proposed detailing technique intends to concurrently improve the seismic and progressive collapse performances of an RC frame by changing the layout of the newly added longitudinal reinforcement against progressive collapse without introducing any additional reinforcement. A six‐story RC frame is used as the prototype building for this investigation. Both cyclic and progressive collapse tests are conducted to validate the performance of the proposed structural detailing. Based on the experimental results, detailed finite element (FE) models of the RC frame with different reinforcement layouts are established. The seismic and progressive collapse resistances of different models are compared based on the incremental dynamic analysis (IDA) and nonlinear dynamic alternate path (AP) methods, respectively. The results indicate that the proposed structural detailing can effectively resolve the conflict between the seismic and progressive collapse designs.