Nanotechnology plays a vital role in medication delivery, and different types of nanoparticles (NPs) have shown unique features that might lead to new therapeutic treatment options. Anti-inflammatory medicines have exploited NP-mediated drug delivery methods. Inflammation’s pathophysiology has a large influence on disorder like as bone, skin, and internal. Anti-inflammatory medication distribution that is efficient can minimize medical dose while also improving therapeutic impact. In this chapter, we examine NPs with possible anti-inflammatory efficacy, as well as a future outlook on nanomedicine’s applicability in inflammatory illnesses.