Epithelial-Mesenchymal Transition and Mesenchymal-Epithelial Transition in Oral Stem Cell Carcinogenesis

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Author(s)
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Lam, Alfred

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Smith, Robert

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Date
2011
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Abstract

Oral squamous cell carcinoma (OSCC), derived from normal oral epithelium transformation, remains a major public health problem world-wide. The prognosis of OSCCs that occur on lips is good, while other sites of oral mucosa where OSCC appears are more progressive, invasive and metastatic. A small subset of cells within a malignant neoplasm, named cancer stem cells (CSCs) or tumour initiating cells are thought to be capable of initiating the neoplasm itself, and of driving its growth and recurrance after treatment. The precise origin of CSCs is an ambiguous issue at present. The first proposal of the origin of CSCs is that CSCs develop from tumour cells themselves via cellular dedifferentiation. The secondary hypothesis for the origin of CSCs proposes that CSCs are the product of malignant transformation of adult stem cells. In this Ph.D thesis, we tried to demonstrate that CSCs in OSCC may be produced from those pathways.

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Thesis Type

Thesis (PhD Doctorate)

Degree Program

Doctor of Philosophy (PhD)

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School of Medicine

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The author owns the copyright in this thesis, unless stated otherwise.

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Public

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The Appendices have not been published. This thesis has been scanned.

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Subject

Oral squamous cell carcinoma

Cancer stem cells

Epithelial-mesenchymal transition

Mesenchymal-epithelial transition

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