Birth outcomes for Australian mother-infant pairs who received an influenza vaccine during pregnancy 2012-2014: The FluMum study (Letter)
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Andrews, Ross M
Ware, Robert S
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Abstract
We thank Drs. Hutcheon and Ortiz for their comments on the potential for immortal time bias arising through the classification of immunization status in our analyses [1], [2]. Specifically, that we classified exposure as a categorical variable (ever vaccinated versus never vaccinated in pregnancy) rather than as a time varying co-variate. We agree that a woman vaccinated in pregnancy contributes both unvaccinated time (the period of pregnancy commencing from a specified gestational age up until the vaccine was received) and vaccinated time (the period of pregnancy commencing from a specified time point post vaccination through until birth or other defined time point). We accept that the potential for immortal time bias should have been included amongst the limitations that we outlined in our paper.
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Vaccine
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35
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35
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Biological sciences
Agricultural, veterinary and food sciences
Biomedical and clinical sciences
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Life Sciences & Biomedicine
Immunology
Medicine, Research & Experimental
Research & Experimental Medicine
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McHugh, L; Andrews, RM; Ware, RS, Birth outcomes for Australian mother-infant pairs who received an influenza vaccine during pregnancy 2012-2014: The FluMum study (Letter), Vaccine, 2017, 35 (35), pp. 4492-4493